產(chǎn)品編號(hào)bs-1937R
英文名稱Zyxin
中文名稱磷酸化斑聯(lián)蛋白抗體
別    名ESP 2; ESP2; HED 2; HED2; ZYX; ZYX protein; Zyxin 2; Zyxin2; Zyxin-2; ZYX_HUMAN.   
規(guī)格價(jià)格0.1ml/980元 購(gòu)買    0.2ml/1580元 購(gòu)買    
說(shuō) 明 書0.1ml  0.2ml  
研究領(lǐng)域染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量61kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀Lyophilized or Liquid
濃    度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Zyxin
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生 產(chǎn) 商BIOSS
PubMedPubMed
磷酸化斑聯(lián)蛋白抗體產(chǎn)品介紹background:
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008].

Function:
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.

Subunit:
Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.

Similarity:
Belongs to the zyxin/ajuba family. 
Contains 3 LIM zinc-binding domains.

Gene ID:
7791

Database links:
Entrez Gene: 7791 Human
Entrez Gene: 22793 Mouse
Entrez Gene: 114636 Rat
Omim: 602002 Human
SwissProt: Q15942 Human
SwissProt: Q62523 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

(Zyxin)與細(xì)胞附著及信號(hào)轉(zhuǎn)導(dǎo)相關(guān),是肌動(dòng)蛋白絲裝配的調(diào)節(jié)物，在結(jié)構(gòu)和功能上將細(xì)胞外配體與細(xì)胞骨架連接。