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RG7112

CAS No. : 939981-39-2

MCE 國際站：RG7112

產品活性：RG7112 是有效的、選擇性的、第一個用于臨床的、可口服的、可透過血腦屏障的、 MDM2-p53 抑制劑，IC₅₀ 值為 18 nM，結合到MDM2 的K_D 值為 11 nM.

研究領域：Apoptosis  |  Metabolic Enzyme/Protease

作用靶點：MDM-2/p53  |  E1/E2/E3 Enzyme

In Vitro: RG7112 (0-5 μM) stabilizes wild-type p53 and induces p53 signaling in cancer cells. RG7112 effectively activates p53 functions in cancer cells.

In Vivo: RG7112 (25-200 mg/kg, single oral dose) activates p53 pathway and induces apoptosis in tumor cells in vivo.
?RG7112 (100 mg/kg, gavage once per day, 5 days/week for 3 weeks ) reduces tumor growth rate and increases survival in GBM models.

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