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Rabbit
WB,ELISA
H,Rat
WB 1:500-2000 ELISA 1:5000-20000
-20°C/1 year
ABCC8 Polyclonal Antibody detects endogenous levels of protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synthesized peptide derived from human protein . at AA range: 500-580
Q09428
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Polyclonal
IgG
ATP binding cassette subfamily C member 8(ABCC8) Homo sapiens The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for
ABCC8 HRINS SUR SUR1, ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1)
1 mg/ml
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