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Rabbit
IF,WB,IHC,ELISA
Human,Rat
IF: 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000
-20°C/1 year
Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400
P29466
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Polyclonal
IgG
caspase 1(CASP1) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
CASP1 IL1BC IL1BCE, Caspase-1
45159
1 mg/ml
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