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Source

Rabbit

Applications

WB,IHC

Reactivity

Mouse,Rat

Dilution

WB: 1:1000 IHC:1:200-500

Storage

-20°C/1 year

Specificity

The antibody detects endogenous 14-3-3 ε protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

Recombinant Protein of 14-3-3 ε

Uniprot No

P62258

Alternative names

YWHAE; 14-3-3 protein epsilon; 14-3-3E

Form

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Clonality

Polyclonal

Isotype

IgG

Background

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon(YWHAE) Homo sapiens This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008],

Other

YWHAE, 14-3-3 protein epsilon

Concentration

1 mg/ml