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Source

Rabbit

Applications

WB,IF,ELISA

Reactivity

Human,Mouse,Rat

Dilution

WB: 1:500 - 1:2000. IF: 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

Adducin β Polyclonal Antibody detects endogenous levels of Adducin β protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human ADD2. AA range:471-520

Uniprot No

P35612

Alternative names

ADD2; ADDB; Beta-adducin; Erythrocyte adducin subunit beta

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

adducin 2(ADD2) Homo sapiens Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region i

Other

ADD2, Beta-adducin

Mol.Wt (Da)

80854

Concentration

1 mg/ml