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Source

Rabbit

Applications

WB, ELISA

Reactivity

Human, Mouse, Rat

Dilution

WB 1:500-2000, ELISA(peptide)1:5000-20000

Storage

-20°C/1 year

Specificity

This antibody detects endogenous levels of human Caspase 10 (p23/17, Cleaved-Val220)

Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen

Synthesized peptide derived from human Caspase 10 (p23/17, Cleaved-Val220)

Uniprot No

Q92851

Alternative names

Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

caspase 10(CASP10) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],

Other

CASP10 MCH4, Caspase 10 (p23/17, Cleaved-Val220)

Concentration

1 mg/ml