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Source

Rabbit

Applications

WB,ELISA

Reactivity

Human

Dilution

WB: 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

Caspase-14 Polyclonal Antibody detects endogenous levels of Caspase-14 protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

Synthesized peptide derived from Caspase-14 . at AA range: 110-190

Uniprot No

P31944

Alternative names

CASP14; Caspase-14; CASP-14

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

caspase 14(CASP14) Homo sapiens This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligａnd in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008],

Other

CASP14, Caspase-14

Mol.Wt (Da)

27680

Concentration

1 mg/ml