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Source

Rabbit

Applications

WB,ELISA

Reactivity

Human

Dilution

WB: 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

CD30-L Polyclonal Antibody detects endogenous levels of CD30-L protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF8. AA range:131-180

Uniprot No

P32971

Alternative names

TNFSF8; CD30L; CD30LG; Tumor necrosis factor ligａnd superfamily member 8; CD30 ligand; CD30-L; CD153

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

tumor necrosis factor superfamily member 8(TNFSF8) Homo sapiens The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligａnd family. This cytokine is a ligａnd for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

Other

TNFSF8, Tumor necrosis factor ligａnd superfamily member 8

Mol.Wt (Da)

26017

Concentration

1 mg/ml