The MP4-25D2 monoclonal antibody reacts with human IL-4 (interleukin-4) a multifunctional 14 kDa cytokine. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4Rα. Upon receptor binding IL-4 stimulates activated B and T lymphocyte proliferation, and the differentiation of B cells into plasma cells. It also induces B cell class switching to IgE, and up-regulates MHC class II production while decreasing the production of Th1 cells, macrophages, IFNγ, and dendritic cell IL-12. Like other Th2 associated cytokines, IL-4 is involved in the airway inflammation observed in the lungs of patients with allergic asthma. The MP4-25D2 monoclonal antibody has been shown to neutralize the bioactivity of natural or recombinant human IL-4.

產(chǎn)品名稱(chēng):InVivoMab anti-human IL-4

反應(yīng)種屬:human

宿主來(lái)源:rat

實(shí)驗(yàn)應(yīng)用:in vitro IL-4 neutralization, Flow cytometry

同種型:IgG1, κ

免疫原:Recombinant human IL-4 expressing CHO cells

克隆性:Monoclonal

克隆號(hào):MP4-25D2

產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml

保存溫度:Undiluted at 4°C in the dark

運(yùn)輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

預(yù)期分子量:150 kDa

產(chǎn)品形式:液體

有效期:One year from the date of receipt if stored as recommended

產(chǎn)地:美國(guó)

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