化工儀器網(wǎng)
資料下載
The Structure-Function Relationship of PAMAM Dendrimers as Robust Oil Dispersants
閱讀：250 發(fā)布時間：2015-3-12| 提 供 商 | 美國布魯克海文儀器公司 | 資料大小 | 1.1MB |
|---|---|---|---|
| 資料圖片 | 下載次數(shù) | 274次 | |
| 資料類型 | PDF 文件 | 瀏覽次數(shù) | 250次 |
| 免費下載 | 點擊下載 |
PAMAM dendrimers have recently been investigated as efficient and biocompatible oil
11 dispersants utilizing their encapsulation capacity; however, their high cationic charge density has
12 been shown to be cytotoxic. It is therefore imperative to mitigate cationic charge-induced
13 toxicity and understand the effects of such changes. Presented here is a synergistic experimental
14 and computational approach to examine the effects of varying terminal surface charge on the
15 capacity of dendrimers to disperse model liner, polycyclic aromatic, and hybrid hydrocarbons.
16 Uncharged dendrimers collapse by forming intra-molecular hydrogen bonds, which reduce the
17 hosting capability. On the other hand, changing the surface charges from positive to negative
18 greatly shifts the pKa of tertiary amines of the PAMAM dendrimer interior. As a result, the
19 negatively charged dendrimers have a significant percentage of tertiary amines protonated,
20 ~30%. This unexpected change in interior protonation state cause electrostatic interactions with
21 the anionic terminal groups, leading to contraction and a marked decrease in hydrocarbon
22 hosting capacity. The present work highlights the robust nature of dendrimer oil dispersion and
also illuminates potentially unintended or unanticipated effects 23 of varying dendrimer surface
24 chemistry on their encapsulation or hosting efficacy, which is important for their environmental,
25 industrial, and biomedical applications.